By Sharma S Prabhakar
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Additional resources for An update on glomerulopathies : clinical and treatment aspects
Further trials are needed to establish whether a different dosage or more prolonged treatment may obtain therapeutic results in IMN 8. Intravenous high-dose immunoglobulins [IVIG] IVIG have been used in high dose in treatment of IMN. IVIG interferes with complementmediated immune damage by binding to C3b and C4b,by this mechanism preventing glomerular injury. This mechanism may be involved in IMN, as suggested by a study in passive Heymann nephritis, in which treatment with systemic immunoglobulin obtained a decrease in proteinuria, associated with a decreased glomerular deposition of C3c and C5b-9, without changes in the amount, size or distribution of the subepithelial immune complexes .
Nephrol. Lupus (2009) 18, 1091–1095 Nayagam L,Ganguli SA. Mycophenolate mofetil or standard therapy for membranous nephropathy and focal segmental glomerulosclerosis: a pilot study Nephrol Dial Transplant (2008) 23: 1926–1930 Pantelista K. Koutroulia E. Sotsiou F. , Oumenos DS: Benefit and cost from the long-term use of cyclosporine-A in idiopathic membranous nephropathy Nephrology 15 (2010) 762–767 Expert Opin. Pharmacothery. J Am Soc Nephrol 21: 697–704, 2010. Ponticelli C,Passerini P. J Nephrology 2010 ; 23 (02): 156-163 Ponticelli C.
2005). The role of the other components of the slit diaphragm in the pathophysiology of FSGS is not yet clear. In summary, these data suggest that mutations in the cytoskeleton and membrane proteins specific to podocytes are responsible for most inherited forms of disease. The frequency of spontaneous mutations in the general population who develop nephrotic syndromes or FSGS still needs to be assessed as it has diagnostic, prognostic and therapeutic implications in case of FSGS. For example, patients who possess genetically defective podocytes should be unresponsive to conventional steroid treatment.
An update on glomerulopathies : clinical and treatment aspects by Sharma S Prabhakar